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簡介:
納米金是指金的粒徑為1-100nm之間的粒子,分散在水溶液或有機溶液中。納米金在一些特定的晶面上存在著表面電子態,其費米能級恰好位于體能帶結構沿該晶向的禁帶中,形成只能平行于表面方向的二維電子云。這是納米金的表面效應,量子效應和宏觀量子隧道效應的物理基礎。納米金隨其直徑由大而小呈現深黃色至黑色,納米金在520nm左右可見光譜范圍之間有一個金的橫向伸縮振動吸收峰,吸收波長隨金粒子粒徑表達而增加,當有納米金棒生成時,在近紅外處就會出現吸收峰。當粒徑從小到大變化時,溶液的顏色這一次表現為深黃色,粉紅色,酒紅色,深紅色,藍色的變化。隨著金納米粒子的聚沉,吸收峰會變寬。膠體金的性質主要取決于納米金粒子的粒徑及其表面修飾。
球形金納米粒子的部分屬性:
粒徑大小 (nm) | 濃度 (mg/ml) | 粒子數(Particles/mL) | SPR Wavelength (nm) |
2 | 0.1 | 1.5x1014 | ~510 |
3 | 0.1 | 1.2x1014 | 512~515 |
5 | 0.1 | 5.0x1013 | 515~520 |
10 | 0.1 | 5.7x1012 | 515~520 |
15 | 0.1 | 1.4x1012 | 525 |
20 | 0.1 | 7.0x1011 | 527 |
30 | 0.1 | 2.0x1011 | ~530 |
40 | 0.1 | 9.0x1010 | ~535 |
50 | 0.1 | 4.5x1010 | ~540 |
80 | 0.1 | 2.6x1010 | ~553 |
100 | 0.1 | 1.1x1010 | ~572 |
150 | 0.1 | 5.6x109 | -- |
200 | 0.1 | 1.7x109 | -- |
納米金棒的部分屬性:
長徑比 | 直徑 (nm) | 濃度 (mg/ml) | SPR Wavelength (nm) | 顏色 |
2.0 | 40 | 0.1 | 660 | 藍色 |
2.5 | 30 | 0.1 | 657 | 藍色 |
3.0 | 30 | 0.1 | 700 | 棕黃色 |
3.2 | 25 | 0.1 | 720 | 棕紅色 |
3.5 | 23 | 0.1 | 805 | 酒紅色 |
4.0 | 29 | 0.1 | 760 | 酒紅色 |
4.3 | 25 | 0.1 | 830 | 酒紅色 |
5.0 | 20 | 0.1 | 960 | 藍色 |
PEG化金納米粒子可以避免納米材料在合成過程中所吸附的表面活性劑(CTAB)所造成的生物毒性,進一步提高其水溶性、生物相容性和體內循環時間,從而獲得更加良好的診斷、成像和光熱治療的能力。通過PEG的官能團-COOH,-NH2,-FA,-Biotin等活性基團連接生物分子,利用生物分子的特異性識別作用,使得金納米粒子表面偶聯特異性分子實現對腫瘤的主動靶向診斷和治療研究。
PEG化納米金棒的部分屬性:
長徑比 | 濃度(mg/ml) | SPR Wavelength (nm) |
2.0 | 0.1 | 680 |
2.5 | 0.1 | 680 |
3.0 | 0.1 | 720 |
3.2 | 0.1 | 735 |
3.5 | 0.1 | 820 |
4.0 | 0.1 | 780 |
4.3 | 0.1 | 855 |
5.0 | 0.1 | 980 |
經PEG修飾后納米金棒表面會帶負電荷
(zeta-AuNRs-CTAB)
(zeta-AuNRs-PEG)
1:聚乙二醇修飾的球形納米金產品:
Gold Nanoparticles,Au-S-PEG-X(末端基團)
PEG分子量:550/750/1000/2000/3400/5000/10000
X末端基團:NH2/COOH/MAL/NHS/BIOTIN/SH/N3/Folate/OPSS/FITC/RB/DSPE/Alkyne
SGA/Silane/OH/PLGA/PLA/PCL/CH3
粒徑:5/10/15/20/30/40/50/60/70/80/90/100nm
2:聚乙二醇修飾的納米金棒(AuNRs)產品:
Gold Nanorods,Au-S-PEG-X(末端基團)
PEG分子量:550/750/1000/2000/3400/5000/10000
X末端基團:NH2/COOH/MAL/NHS/BIOTIN/SH/N3/Folate/OPSS/FITC/RB/DSPE/Alkyne
SGA/Silane/OH/PLGA/PLA/PCL/CH3
聚乙二醇修飾的納米金及納米金棒的價格表:
Gold Nanoparticles,Au-S-PEG-Methoxy
PEG分子量:550/750/1000/2000/3400/5000/10000 ,粒徑:5nm-100nm
低濃度:0.1mg/ml 2800元/25ml, 4200元/50ml
高濃度:0.5mg/ml 4200元/25ml, 6500元/50ml
Gold Nanoparticles,Au-S-PEG-Amine(NH2)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Carboxyl(COOH)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Maleimide(MAL)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-NHS (NHS)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Biotin (Biotin)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Azide (N3)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Folic acid (FA)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-OPSS (OPSS)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG- Fluorescein (FITC)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 5200元/25ml, 7800元/50ml
高濃度:0.5mg/ml 7800元/25ml, 9000元/50ml
Gold Nanoparticles,Au-S-PEG-RhodamineB (RB)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 5200元/25ml, 7800元/50ml
高濃度:0.5mg/ml 7800元/25ml, 9000元/50ml
Gold Nanoparticles,Au-S-PEG-DSPE (DSPE)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 5200元/25ml, 7800元/50ml
高濃度:0.5mg/ml 7800元/25ml, 9000元/50ml
Gold Nanoparticles,Au-S-PEG-Cholesterol (CHOL)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 5200元/25ml, 7800元/50ml
高濃度:0.5mg/ml 7800元/25ml, 9000元/50ml
Gold Nanoparticles,Au-S-PEG-Alkyne(ALK)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-OH(OH)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-OH(OH)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-Silane(Silane)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/25ml, 7500元/50ml
Gold Nanoparticles,Au-S-PEG-PLGA(PLGA)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 6500元/25ml, 8300元/50ml
高濃度:0.5mg/ml 8300元/25ml, 9500元/50ml
Gold Nanoparticles,Au-S-PEG-PLA(PLA)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 6500元/25ml, 8300元/50ml
高濃度:0.5mg/ml 8300元/25ml, 9500元/50ml
Gold Nanoparticles,Au-S-PEG-PCL(PCL)
PEG分子量:550/750/1000/2000/3400/5000/10000 粒徑:5nm-100nm
低濃度:0.1mg/ml 6500元/25ml, 8300元/50ml
高濃度:0.5mg/ml 8300元/25ml, 9500元/50ml
Gold Nanorods,Au-S-PEG-Methoxy
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Amine(NH2)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Carboxyl (COOH)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Maleimide (MAL)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-NHS (NHS)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Biotin (Biotin)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Azide (N3)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Folic acid (FA)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 4900元/25ml, 7500元/50ml
高濃度:0.5mg/ml 7250元/10ml, 9700元/25ml
Gold Nanorods,Au-S-PEG-OPSS (OPSS)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG- Fluorescein (FITC)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 4900元/25ml, 7500元/50ml
高濃度:0.5mg/ml 7250元/10ml, 9700元/25m
Gold Nanorods,Au-S-PEG-RhodamineB (RB)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 4900元/25ml, 7500元/50ml
高濃度:0.5mg/ml 7250元/10ml, 9700元/25m
Gold Nanorods,Au-S-PEG-DSPE (DSPE)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 4900元/25ml, 7500元/50ml
高濃度:0.5mg/ml 7250元/10ml, 9700元/25m
Gold Nanorods,Au-S-PEG-Cholesterol (CHOL)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 4900元/25ml, 7500元/50ml
高濃度:0.5mg/ml 7250元/10ml, 9700元/25m
Gold Nanorods,Au-S-PEG-Alkyne(ALK)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-OH(OH)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-Silane(Silane)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 3800元/25ml, 5500元/50ml
高濃度:0.5mg/ml 5300元/10ml, 7500元/25ml
Gold Nanorods,Au-S-PEG-PLGA(PLGA)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 6800元/25ml, 9500元/50ml
高濃度:0.5mg/ml 9200元/10ml, 13000元/25ml
Gold Nanorods,Au-S-PEG-PLA(PLA)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 6800元/25ml, 9500元/50ml
高濃度:0.5mg/ml 9200元/10ml, 13000元/25ml
Gold Nanorods,Au-S-PEG-PCL(PCL)
PEG分子量:550/750/1000/2000/3400/5000/10000 SPR peak600-1000nm
低濃度:0.1mg/ml 6800元/25ml, 9500元/50ml
高濃度:0.5mg/ml 9200元/10ml, 13000元/25ml
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